Pyrimido- and imidazo-pyridoindole derivatives
AssigneeSynthelabo
InventorsGabor I. Koletar, Jonathan R. Frost, Regis DuPont, Patrick Lardenois, Claude Morel, Henry Najer
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Abstract
Pyrimido- and imidazo-pyridoindole derivatives, in the form of racemates or optically active isomers, of formula: ##STR1## in which n=0 or 1, R.sub.1 =H, Hal, alkyl or alkoxy or CF.sub.3, R.sub.2 =H, alkyl, cycloalkyl-alkyl, cycloalkyl, N,N-dialkylaminoalkyl or phenyl, R.sub.3 =H or alkyl and R.sub.4 =H, alkyl or benzyl are useful as anti-anoxia or psychotropic agents in therapy. They are prepared by cyclizing a compound of formula: ##STR2## wherein R.sub.5 is alkyl, by heating it in an acidic medium, such as ethanolic hydrogen chloride.
Claims7
A compound of the formula ##STR10## in which n is 0 or 1, R is hydrogen, halogen, alkyl, alkoxy, or trifluoromethyl;
- R.sub.2 is hydrogen, alkyl, cycloalkyl-alkyl, cycloalkyl, N,N-dialkylaminoalkyl or phenyl which is unsubstituted or substituted by halogen, R.sub.3 is hydrogen or alkyl;
- and R.sub.4 is hydrogen, alkyl, or benzyl, each alkyl and alkoxy having from 1 to 4 carbon atoms and each cycloalkyl having from 3 to 6 carbon atoms, or a pharmaceutically acceptable salt thereof, except the compounds in which simultaneously n=1, R.sub.2 is hydrogen, ethyl, n-butyl, or phenyl and R.sub.1, R.sub.3 and R.sub.4 are all hydrogen, said compound being a racemate or optically active isomer.
Dependencies are inferred from the claim text.