Nicotinic derivatives of glucosamine and related pharmaceutical compositions
AssigneeLaboratorio Guidotti & C. S.p.A.
InventorsWalter Murmann, Osvaldo Ponchiroli
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Abstract
The nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate are described as having anti-lipolitic, hypocholesterolemizing and antiaterogenic activities, at an equal or higher level than those of nicotinic acid, without the objectionable side effects shown by the acid. To prepare the compounds of the invention, nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40.degree. C. and 120.degree. C.
Claims7
A nicotinic derivative of glucosamine selected from the group of compounds having the formula:
- ##STR5## wherein R.sub.1 represents H or the radical of nicotinic acid and R.sub.2 is the radical of nicotinic acid, and their non toxic, pharmaceutically acceptable acid salts.
Dependencies are inferred from the claim text.