Back to results
US 4,357,342 AGranted
1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, Ronald W. Ratcliffe
Life of this patent
Estimating the term…
Abstract
Disclosed are the pharmaceutically acceptable salt and ester forms of 1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid (I): ##STR1## Such compounds are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
Claims2
A compound having the structure:
- ##STR32## wherein:
- R is hydrogen;
- an alkali, alkaline earth, or amine cation selected from the group consisting of:
- sodium, potassium, calcium, benzhydrylamine, N-benzyl-2-phenethylamine, N,N'-dibenzylethylenediamine, procaine;
- or an ester moiety selected from:
- methallyl, 3-methylbutenyl, 3-butenyl, methylthioethyl, benzyl, p-t-butylbenzyl, m-phenoxybenzyl, p-pivaloyloxy-benzyl, p-nitrobenzyl, pivaloyloxymethyl, 3-phthalidyl, acetoxymethyl, propionyloxymethyl, acetylthiomethyl, pivaloylthiomethyl, allyl, 4-butenyl, 2-butenyl, 3-methyl-2-butenyl, phenacyl, acetoxyacetylmethyl, methoxymethyl, p-acetoxybenzyl, p-pivaloyloxybenzyl, p-isopropoxybenzyl, 5-indanylmethyl, 5-indanyl, benzyloxymethyl, ethylthioethyl, methylthiopropyl, methoxycarbonyloxymethyl, ethoxycarbonyloxymethyl, dimethylaminoacetoxymethyl, crotonolacton-3-yl, and acetamidomethyl.
3 more elements
Dependencies are inferred from the claim text.