Imidazole derivatives and angina pectoris

A method of prevention, treatment or prophylaxis of angina pectoris in a mammal in need thereof which comprises administering to said mammal an effective amount of an angina pectoris prevention, treatment or prophylaxis

• 1-substituted-imidazole of the formula:
• ##STR21## in which A is selected from the group consisting of straight or branched, saturated, acyclic hydrocarbon radicals of 1, 2 or 3 carbon atoms, and straight or branched unsaturated acyclic hydrocarbon radicals of 2 or 3 carbon atoms, and
• R is ##STR22## wherein n is an integer which is at least 1, and the or each Q substituent, which when n is greater than 1 may be the same or different, is selected from a saturated hydrocarbon group of from 1 to 4 carbon atoms and an unsaturated hydrocarbon group of from 2 to 4 carbon atoms, with the provisos that
• (a) when A is a methylene or ethylidene group, n is at least 2 when each Q is a saturated hydrocarbon group;
• (b) when A is a branched propylene or straight propylidene group, n is at least 3 when each Q is a saturated hydrocarbon group;
• and
• (c) when A is unsaturated Q may also be selected from alkoxy of from 1 to 4 carbon atoms;
• halo;
• trihalomethyl;
• hydroxy;
• carboxyl;
• a pharmaceutically acceptable salt of such a carboxyl group;
• carboalkoxy with 1 to 4 carbon atoms in the alkoxy portion thereof;
• --NR.sup.6 R.sup.7 or --CONR.sup.6 R.sup.7 ;
• in which R.sup.6 and R.sup.7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms, with the further proviso that when n is 1, Q is not a saturated alkyl group;
• the substituted-imidazole being the free base or a pharmaceutically acceptable acid addition salt thereof.