Hypotensive imidazole-5-acetic acid derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsYoshiyasu Furukawa, Shoji Kishimoto, Kohei Nishikawa
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Abstract
Novel imidazole-5-acetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl, cycloalkyl or, phenyl which may be substituted with one to three of halogen, nitro, amino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl; X.sup.1, X.sup.2 and X.sup.3 are each hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl; Y is halogen and R.sup.2 is hydrogen or lower alkyl; provided that X.sup.1 is halogen, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl when R.sup.1 is unsubstituted or substituted phenyl only with one halogen, di(lower alkyl)amino, lower alkyl or lower alkoxyl, and its salts have hypotensive activity.
Claims17
A compound of the formula:
- ##STR138## wherein alk is lower alkyl or lower cycloalkyl;
- each of X.sup.1, X.sup.2 and X.sup.3 is independently hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl;
- Y is halogen and R.sup.2 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- ##STR139## wherein R.sup.1 is phenyl which is substituted with only one nitro, amino, monobutylamino or hydroxyl, or with two or three of halogen, nitro, amino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl groups;
- each of X.sup.1, X.sup.2 and X.sup.3 is independently hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl;
- Y is halogen and R.sup.2 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- ##STR140## wherein R.sup.1 is unsubstituted phenyl or phenyl substituted only with one halogen, di(lower alkyl)amino, lower alkyl or lower alkoxyl;
- X.sup.1 is halogen, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl, and each of X.sup.2 and X.sup.3 is independently hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl;
- Y is halogen and
- R.sup.2 is hydrogen or lower alkyl
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.