Chlorocitric acids
AssigneeHoffmann-La Roche Inc.
InventorsRobert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
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Abstract
The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
Claims10
A process for the preparation of a chlorocitric acid of the formula ##STR38## and stereoisomers and optical antipodes thereof which comprises the step of contacting an epoxyaconitic acid of the formula ##STR39## and stereoisomers and optical antipodes thereof, with an alkali metal chloride or an alkaline earth metal chloride in an aqueous solvent in the presence of about one molar equivalent of hydrochloric acid at a reaction temperature of about 50.degree. C. to 80.degree. C.
Dependencies are inferred from the claim text.