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US 4,350,638 AGranted
Bruceolides
AssigneeResearch Corporation
InventorKuo-Hsiung Lee
Life of this patent
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Abstract
There are provided two synthetic routes to the known potent anti-leukemic quassinoid bruceantin from the more readily available bruceoside-A and -B. Certain of the intermediate compounds produced in the synthetic sequence as well as bruceantin itself have been shown to possess anti-malarial properties.
Claims1
A compound of the formula ##STR1## wherein R.sub.3 is benzoyl, trimethoxybenzoyl, bruceantinyl malonyl, bruceantinyl succinoyl, bruceantinyl glutaroyl, and lower alkanoyl at 1 to 5 carbon atoms, brusatolyl malonyl, brusatolyl succinoyl, brusatolyl glutaroyl,
- R.sub.15 is benzoyl, trimethoxybenzoyl, dihydrosenecioyl and lower alkanoyl 1 to 5 carbon atoms or senecioyl where R.sub.3 is brusatolyl succinoyl or brusatolyl glutaroyl,
- R.sub.11 and R.sub.12 are hydrogen or lower alkanoyl of 1 to 5 carbon atoms.
Dependencies are inferred from the claim text.