Process for the preparation of penicillin derivatives
AssigneeBeecham Group Limited
InventorsMartin Cole, Robert A. Edmondson
Life of this patent
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Abstract
A process for the preparation of .alpha.-carboxy, 6, .alpha.-methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative. The process is for the preparation of a compound of formula (I): ##STR1## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR2## where R.sup.1 is an aryl radical, to the action of an enzyme selected from bromelain, papain, gelatase, trypsin, pancreatin or an esterase-producing strain of Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger or Saccharomyces sp.
Claims7
A process for the preparation of a 6.alpha.-methoxy penicillin formula (I):
- ##STR8## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV):
- ##STR9## where R.sup.1 is an aryl radical , to the action of an enzyme selected from the group consisting of bromelain, papain, gelatase, trypsin, pancreatin and an esterase-producing strain of Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, and Saccharomyces sp.
Dependencies are inferred from the claim text.