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US 4,346,078 AGranted
Novel anticoagulant agmatine derivatives and process for the preparation thereof
AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsSandor Bajusz, Erzsebet Szell nee Hasenohrl, Eva Barabas, Daniel Bagdy, Zsuzsanna Mohai nee Nagy
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Abstract
Anti-coagulants of the formula X-Pro-Agm(HB) (.sub.n) wherein X is an alpha-amino acid moiety of the configuration having a phenyl, phenyl-(lower)-alkyl or phenyl-(heteroatom-containing) lower alkyl side chain, Agm is an agmatine group (1-amino-4-guanidino-butane), B is an acid residue, and n is an integer from 0-2, are disclosed.
Claims8
An agmatine compound or a pharmaceutically effective salt thereof of the formula I:
- X--Pro--Agm.multidot.(HB).sub.n
- wherein
- X is an .alpha.-amino acid moiety of D-configuration, having a phenyl, phenyl-lower-alkyl, or phenyl-lower alkyl wherein the lower alkyl is interrupted by an oxygen atom,
- Pro is an L-proline residue,
- Agm is an agmatine group,
- B is chloride and
- n is 0, 1 or 2.
4 more elements
Dependencies are inferred from the claim text.