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US 4,345,084 AGranted
Unsaturated eicosanoic acids
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, George W. Holland, Perry Rosen
Life of this patent
Estimating the term…
Abstract
Unsaturated eicosanoic acids and derivatives thereof which inhibit the synthesis of SRS-A are useful for treating and preventing asthma and allergic responses caused by SRS-A as well as useful in inhibiting inflammation.
Claims9
A compound of the formula ##STR31## wherein R is ##STR32## R.sub.1 is hydrogen or fluoro;
- A and B are individually hydrogen or taken together from a carbon to carbon bond with a cis configuration;
- E and G are individually hydrogen or taken together form a carbon to carbon bond with a cis configuration with the proviso that at least one of A and B taken together or E and D taken together form a carbon to carbon bond with a cis configuration;
- and R.sub.2 and R.sub.3 are hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
1 more element
A compound of the formula ##STR33## wherein R is ##STR34## and R.sub.2 and R.sub.3 are hydrogen;
- and .DELTA. designates a cis double bond.
A compound of the formula:
- ##STR35## wherein R is ##STR36## R.sub.1 is hydrogen, alkali metal, alkaline earth metal, or lower alkyl;
- and R.sub.2 and R.sub.3 are hydrogen or lower alkyl, or magnesium halide salts thereof.
Dependencies are inferred from the claim text.