Antiandrogenic 17.alpha.-substituted steroids
AssigneeSchering Corporation
InventorsRudolf Wiechert, Dieter Bittler, Annerose Schleusener, Manfred Albring
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Abstract
17.alpha.-substituted steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms, X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
Claims11
A 17.alpha.-substituted steroid of the formula ##STR4## wherein R.sub.1 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 -alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl,
- R.sub.2 is C.sub.2-6 -alkenyl,
- X is oxygen or H(OR.sub.3) wherein R.sub.3 is hydrogen, an acyl group of a C.sub.1-17 optionally substituted, hydrocarbon carboxylic or sulfonic acid, C.sub.1-5 alkyl, C.sub.1-5 -alkenyl, C.sub.1-5 -alkyl or C.sub.1-5 alkenyl interrupted by an oxa atom, cyclopentyl or tetrahydropyranyl.
Dependencies are inferred from the claim text.