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US 4,343,949 AGranted
Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
AssigneeAmerican Cyanamid Company
InventorsKarel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
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Abstract
This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
Claims3
A method comprising rearranging the compound of the formula:
- ##STR37## wherein p is an integer from 3 to 6 inclusive, by treating said compound at room temperature with an aqueous medium having a pH of about 10.3 to 10.6 to provide the compound of the formula:
- ##STR38## wherein p is an integer from 3 to 6 inclusive.
Dependencies are inferred from the claim text.