Aminocyclopentane alkenoic acids and esters and pharmaceutical compositions
AssigneeGlaxo Group Limited
InventorsEric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw, Norman F. Hayes
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AssigneeGlaxo Group Limited
InventorsEric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw, Norman F. Hayes
Estimating the term…
Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--; R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl; Y is a saturated heterocyclic amino group having 5-8 ring members; and R.sup.2 is C.sub.2-4 alkanoyl, C.sub.3-6 alkenyl (optionally substituted), C.sub.1-12 alkyl, or substituted or unsubstituted phenylalkyl, biphenylalkyl or naphthylalkyl. These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
Compounds of the general formula (1) ##STR12## wherein X is cis or trans -CH.dbd.CH-;
[1.alpha.(Z),2.beta.,5.alpha.] -(.+-.)-7-[5-[[(1,1'-biphenyl)-4-yl]methyoxy]-2-(4-morpholinyl)-3-oxocyclop entyl]-4-heptenoic acid or a physiologically acceptable salt or solvate thereof.
[1R[1 .alpha.(Z),2.beta.,5.alpha.]]-(-)-7-[5-[[(1,1'-biphenyl)-4-yl]methoxy]-2-(4 -morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid or a physiologically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.