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US 4,341,708 AGranted
Prostacyclin aza analogue intermediates
AssigneeBeecham Group Limited
InventorsFrederick Cassidy, Keith H. Baggaley, Arthur W. R. Tyrrell
Life of this patent
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Abstract
An intermediate compound which is a perhydrofuro [3,2-6] pyrrole of the formula: ##STR1## wherein: R.sub.2 is hydrogen or C.sub.1-4 alkyl; and R.sub.3 is C.sub.4-9 alkyl, C.sub.5-7 cycloalkyl or C.sub.5-7 cycloalkyl C.sub.1-6 alkyl; for use in the synthesis of prostacyclin aza analogues having anti-thrombotic activity.
Claims1
A compound selected from the group consisting of a perhydrofuro[3,2-b]pyrrole of the formula:
- ##STR66## and the benzyl ethers thereof, wherein
- R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms and
- R.sub.3 is alkyl of 4 to 9 carbon atoms, cycloalkyl of 5 to 7 carbon atoms or alkyl of 1 to 6 carbon atoms substituted with cycloalkyl of 5 to 7 carbon atoms.
Dependencies are inferred from the claim text.