Cytotoxic products formed by covalent bonding of the A chain of ricin with an antibody and the process for their preparation and use
AssigneeC M Industries
InventorsGuy Voisin, Franz Jansen, Pierre Gros
Life of this patent
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Abstract
Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognizing a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the A chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.
Claims14
Process for the preparation of a cytotoxic product having a covalent disulphide bond between a cytotoxic compound and an antibody, the process comprising forming a disulphide bridge between the A chain of ricin and the antibody, the antibody being an immunoglobulin or an immunoglobulin fragment and being specific for a given antigen carried by the cells which are to be destroyed.
A cytotoxic product, consisting in compounds called "conjugates", wherein the A chain of ricin is coupled by a disulphide bridge to a protein structure which is an antibody, the protein structure being capable of selectively recognising an antigen presented at the surface of the carrier cells and the antibody being an immunoglobulin or an immunoglobulin fragment.
Dependencies are inferred from the claim text.