Benzothiadiazines having diuretic activity
AssigneeE. R. Squibb & Sons, Inc.
InventorRudiger D. Haugwitz
Life of this patent
Estimating the term…
Abstract
Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy; R.sub.3 is hydrogen, alkyl, or phenylmethyl; R.sub.4 is hydrogen, alkyl, or phenyl, and R.sub.15 is alkyl, phenyl or phenylmethyl, or R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- wherein m is 1 or 2; R.sub.5,R.sub.6,R.sub.7,R.sub.8,R.sub.9,R.sub.10,R.sub.11,R.sub.12,R.sub.13 and R.sub.14 are each independently hydrogen, halogen, alkyl or phenyl; n.sub.1,n.sub.2,n.sub.3,n.sub.4 and n.sub.5 are each independently 0 or 1; with the proviso that if R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- the sum of n.sub.1, n.sub.2, n.sub.3, n.sub.4, n.sub.5 and m is 2 or 3; have diuretic activity.
Claims9
A compound having the formula ##STR10## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy;
- R.sub.3 is hydrogen, alkyl, or phenylmethyl;
- R.sub.4 is hydrogen, alkyl, or phenyl, and R.sub.15 is alkyl, phenyl or phenylmethyl, or R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- wherein m is 1 or 2;
- R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13 and R.sub.14 are each independently hydrogen, halogen, alkyl or phenyl;
- n.sub.1, n.sub.2, n.sub.3, n.sub.4, and n.sub.5 are each independently O or 1;
- with the proviso that if R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m --, the sum of n.sub.1, n.sub.2, n.sub.3, n.sub.4, n.sub.5 and m is 2 or 3.
Dependencies are inferred from the claim text.