Fluorinated aromatic polyenes
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, Beverly A. Pawson
Life of this patent
Estimating the term…
Abstract
Compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.
Claims11
Ethyl-3-[4-methoxy-2,3,6-trimethylphenyl]-2-fluoro-2(Z,E)-propenoate.
3-(4-methoxy-2,3,6-trimethylphenyl)-2-fluoro-2(Z,E)-propenoic acid.
Ethyl 2-fluoro-4-methyl-6-acetoxy-2(Z,E),4(E)-hexadienoate.
Ethyl 2-fluoro-4-methyl-6-oxo-2(Z,E),4(E)-hexadienoate.
Ethyl 2-fluoro-4-methyl-6,6-dimethoxy-2(Z,E),4(E)-hexadienoate.
(E,Z,E)-4-fluoro-3,7-dimethyl-8-oxo-2,4,6-octatrienoic acid and its lower alkyl esters.
2(E),4(E),6(Z)-3-methyl-6-fluoro-7-formyl-2,4,6-octatrienoic esters.
2(E,Z),4(E),6(E)-3-methyl-6-fluoro-7-formyl-2,4,6-octatrienoic acid and its lower alkyl esters.
(E/Z,E)-2-fluoro-6,6-dimethoxy-5-methyl-2,4-hexadienoic acid and its lower alkyl esters.
(E/Z,E)-2-fluoro-6,6-dimethoxy-5-methyl-2,4-hexadienoic acid and salts thereof.
Ethyl (E)- and (Z)-2-fluoro-4,4-dimethoxy-3-methyl-2-butenoate.
Dependencies are inferred from the claim text.