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US 4,336,381 AGranted
5-Fluorouracil derivatives
AssigneeShionogi & Co., Ltd.
InventorsWataru Nagata, Susumu Kamata
Life of this patent
Estimating the term…
Abstract
Orally administrable 5-fluorouracil derivatives of the general formula: ##STR1## [wherein R.sup.1 is aryl or substituted aryl; R.sup.2 is acyclic or cyclic alkyl, adamantyl, aryl or substituted aryl; R.sup.3 and R.sup.4 are the same or different, each representing hydrogen atom or lower alkyl] effective against malignant tumors.
Claims13
A compound of the formula ##STR32## wherein R.sup.1 is C.sub.6 to C.sub.10 aryl or C.sub.6 to C.sub.10 aryl substituted by halogen, C.sub.1 to C.sub.5 alkyl, C.sub.1 to C.sub.5 haloalkyl, C.sub.1 to C.sub.5 alkoxy, nitro, cyano or carboxy,
- R.sup.2 is C.sub.1 to C.sub.30 straight or branched chain alkyl, C.sub.3 to C.sub.11 cyclic alkyl wherein the cyclic moiety is 3 to 6 membered, adamantyl, C.sub.6 to C.sub.10 aryl or C.sub.6 to C.sub.10 aryl substituted by halogen, C.sub.1 to C.sub.5 alkyl, C.sub.1 to C.sub.5 haloalkyl, C.sub.1 to C.sub.5 alkoxy, nitro, cyano or carboxy, and
- R.sup.3 and R.sup.4 are the same or different and each is hydrogen or lower alkyl.
Dependencies are inferred from the claim text.