Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsArthur R. McFadden, Daniel E. Aultz
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Abstract
The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R.sup.4 is a hydrogen or an alkyl; R.sup.1 is hydrogen or alkyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen, alkyl or R.sup.2 and R.sup.3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is ##STR3## where R.sup.4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.
Claims87
A compound depicted by the formula, ##STR35## where R is selected from ##STR36## where R.sup.4 is selected from H or alkyl;
- R.sup.1 is hydrogen or alkyl;
- R.sup.2 and R.sup.3 are the same or different and are selected from H, and alkyl or R.sup.2 and R.sup.3 are fused to form the pyrrolidinyl, morpholino, piperidinyl and azepinyl group;
- Y is selected from H, halogen and alkoxy;
- X is selected from ##STR37## where R.sup.4 is as defined above;
- m is an integer of 0 or 1 and n is an integer of 2 or 3, and the pharmaceutically acceptable salts thereof.
A diuretic composition which comprises a diuretically effective amount of a compound ##STR39## where R is selected from ##STR40## where R.sup.4 is selected from H, and alkyl;
- R.sup.1 is selected from H and alkyl;
- R.sup.2 and R.sup.3 are the same or different and are selected from H and alkyl or R.sup.2 and R.sup.3 are fused to form the pyrrolidinyl, morpholino, piperidinyl and azepinyl ring substituent;
- Y is selected from H, halogen and alkoxy;
- X is selected from ##STR41## where R.sup.4 is as defined above;
- m is an integer of 0 or 1;
- and n is an integer of 2 or 3, and the pharmaceutically acceptable salts thereof.
A method of producing diuresis which comprises administering to a mammal a diuretically effective amount of a compound depicted by the formula, ##STR43## where R is selected from ##STR44## where R.sup.4 is selected from H and alkyl;
- R.sup.1 is selected from H and alkyl;
- R.sup.2 and R.sup.3 are the same or different and are selected from H and alkyl or R.sup.2 and R.sup.3 are fused to form the pyrrolidinyl, morpholino, piperidinyl and azepinyl group;
- Y is selected from H, halogen and alkoxy;
- X is selected from ##STR45## where R.sup.4 is as defined above;
- m is an integer selected from 0 and 1;
- and n is an integer selected from 2 and 3;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.