Method of inhibiting dextransucrase and oral compositions for use therein
AssigneeIowa State University Research Foundation, Inc.
InventorsJohn F. Robyt, John N. Zikopoulos
Life of this patent
Estimating the term…
Abstract
Dextransucrase synthesis of dextran from sucrose is inhibited by substituted sucrose compounds which have an inhibiting group bonded to the 5-position ring carbon. Oral compositions containing such substituted sucrose compounds can be used to control dextran formation in the mouth, and dextran comprises the principal component of dental plaque.
Claims14
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of a substituted sucrose compound, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH.sub.2 X, .dbd.CH.sub.2, --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N.sub.3, --NH.sub.2, --OCH.sub.3, and --H.
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of a substituted sucrose compound effective for inhibiting the dextransucrase synthesis of dextran, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH.sub.2 X, .dbd.CH.sub.2, --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N.sub.3, --NH.sub.2, --OCH.sub.3, and --H.
Dependencies are inferred from the claim text.