Growth promotors for ruminants
AssigneeBeecham Group Limited
InventorBrian G. McDonald
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Abstract
Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, halogen or C.sub.1-4 alkoxy; X is oxygen; NR.sup.3 in which R.sup.3 is hydrogen, C.sub.1-4 alkyl, or -Y-R.sup.2 ; --C.dbd.O; or --CHOH; Y is --CH.sub.2 --CHOH, and when X is --C.dbd.O it may also be --CH.dbd.CH--; and R.sup.2 is C.sub.1-4 alkyl, one carbon atom of which is di- or tri-halogenated; or salts thereof, are useful in promoting growth of ruminants. Processes for their production, veterinary formulations and treatments are described.
Claims25
The method of promoting growth in ruminants by inhibiting methane production and enhancing proprionate production which comprises orally administering to a ruminant an effective nontoxic amount of a compound of the formula:
- ##STR22## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, halo or alkoxy of 1 to 4 carbon atoms;
- X is oxygen, carbonyl, hydroxymethylene or NR.sup.3 in which R.sup.3 is hydrogen, alkyl of 1 to 4 carbon atoms or -YR.sup.2,
- Y is --CH.sub.2 CHOH-- or, provided X is carbonyl, --CH.dbd.CH;
- and
- R.sup.2 is alkyl of 1 to 4 carbon atoms, one carbon atom of which is di- or trihalogenated.
A non-toxic veterinary composition for promoting the growth of ruminants, comprising a growth-promoting effective amount of a compound of the formula:
- ##STR23## wherein R.sup.1 is hydrogen, halo or alkoxy of 1 to 4 carbon atoms, X is oxygen, carbonyl, hydroxymethylene, imino, N-alkylimino wherein alkyl contains 1 to 4 carbon atoms or N-(3,3,3,-trichloro-2-hydroxypropyl)-imino;
- and Y is --CH.sub.2 CH(OH)-- or, if X is carbonyl, Y is --CH.sub.2 CH(OH)-- or ethylene, or a salt thereof, in combination with a food stuff for the ruminant, said compound being present in said food stuff in an amount of from 1 to 1000 ppm.
The method according to claim 22 wherein said compound is 1,1,1-trichloro-3-phenoxypropan-2-ol.
Dependencies are inferred from the claim text.