3-[(8-Carboxy-6-tetraz olo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyim ino-acetamido]-3-cephem-4-carboxylic acid
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsGiuliano Nannini, Ettore Perrone, Ferruccio Casabuona, Silvio Grasso
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Abstract
Heterocyclyl derivatives of oxy-imino-substituted cephalosporins are disclosed, such, for instance the compound 3-[(8-amino-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thi azolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid and its pharmaceutically and veterinarily acceptable salts. The compounds of the application have high antibacterial activity against Gram-positive and Gram-negative bacteria, including strong beta-lactamase producer Gram-negative microorganisms.
Claims5
3-[(8- carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazoly l)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid and its pharmaceutically and veterinarily acceptable salts.
3-[(8-carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thio methyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carb oxylic acid (syn-isomer) and its pharmaceutically and veterinarily acceptable salts.
Dependencies are inferred from the claim text.