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US 4,331,598 AGranted
Maytansinoids
AssigneeTakeda Chemical Industries, Ltd.
InventorsToru Hasegawa, Motowo Izawa, Seiichi Tanida
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Abstract
Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent, have antiprotozoan and antitumor activities.
Claims8
A compound of the formula:
- ##STR10## wherein R is --COCH.sub.3, --COCH.sub.2 CH.sub.3, ##STR11## and R.sub.1 is hydrogen or R.sub.2 CO-- in which R.sub.2 is phenyl or alkyl of 1 to 5 carbon atoms, the alkyl being optionally substituted by phenyl.
Dependencies are inferred from the claim text.