Non-thrombogenic material comprising substrate which has been reacted with heparin
AssigneeNippon Zeon Co., Ltd.
InventorYasushi Joh
Life of this patent
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Abstract
Non-thrombogenic material comprising a base polymer treated with heparin, the improvement in which the heparin is covalently bonded with the base polymer through only one acetal bond or hemiacetal bond at each bonding site between the heparin and the base polymer.
Claims8
A shaped article comprising a hollow fiber having an interior wall with a non-thrombogenic surface, said non-thrombogenic surface being prepared by reacting an aldehyde group or aldehyde groups or an aldehyde forming group or aldehyde forming groups on the interior wall with heparin.
A shaped article selected from the group consisting of a tube, a hollow fiber, a film and a sheet, coated with a non-thrombogenic material prepared by reacting cellulose ester with a cleaving agent to develop adjacent aldehyde groups on said cellulose ester and binding heparin to said adjacent aldehyde groups through acetal bond or hemiacetal bond at each bonding site between said heparin and said cellulose ester.
Dependencies are inferred from the claim text.