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US 4,327,022 AGranted
Heterocyclic alkyl naphthols
AssigneeSterling Drug Inc.
InventorDenis M. Bailey
Life of this patent
Estimating the term…
Abstract
Aminoalkylnaphthols and esters thereof, useful as cardiotonic or antibacterial agents, are prepared from the corresponding RO-naphthalenealkylamines, certain of which are also useful as cardiotonic agents.
Claims16
A compound having the formula ##STR71## wherein the side chain represented by ##STR72## occupies either position 5 or position 6 of the naphthalene nucleus;
- R and R.sub.1 are independently hydrogen, lower-alkanoyl, benzoyl or benzoyl substituted by from 1 to 2 lower-alkyl groups;
- Q is hydrogen or methyl;
- A is a direct linkage or CR.sub.5 R.sub.6 where R.sub.5 and R.sub.6 are independently hydrogen or methyl;
- R.sub.2 is hydrogen or methyl, provided that when A is a direct linkage, or when R.sub.5 and/or R.sub.6 are methyl, then R.sub.2 is hydrogen;
- NR.sub.3 R.sub.4 is pyrrolidino, piperidino, hexamethyleneimino, morpholino or any of these having from one to two loweralkyl substituents;
- or an acid-addition salt thereof.
3 more elements
A compound having the formula ##STR73## wherein the side chain represented by ##STR74## occupies either position 7 or position 8 of the naphthalene nucleus;
- R and R.sub.1 are independently hydrogen, lower alkanoyl, benzoyl or benzoyl substituted by from 1 to 2 lower-alkyl groups;
- R.sub.5 and R.sub.6 are independently hydrogen or methyl;
- NR.sub.3 R.sub.4 is pyrrolidino, piperidino, hexamethyleneimino, morpholino or any of these having from one to two lower-alkyl substituents;
- or an acid-addition salt thereof.
1 more element
Dependencies are inferred from the claim text.