Prostacyclin compounds
AssigneeSankyo Company, Limited
InventorsKoichi Kojima, Kiyoshi Sakai, Shinsaku Kobayashi
Life of this patent
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Abstract
Prostacyclin derivatives of formula (I): ##STR1## (wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an alkenyl group having from 8 to 12 carbon atoms; and n represents an integer of from 1 to 8, inclusive) and pharmaceutically acceptable salts thereof, are valuable pharmaceuticals, showing excellent thrombocyte agglutination inhibitory, coronary blood vessel dilatory and bronchodilatory effects, and may be prepared by introducing the .dbd.CH(CH.sub.2).sub.n COOR.sup.1 side chain onto an appropriate compound by means of a Wittig reaction.
Claims22
Compounds of formula (I):
- ##STR35## wherein:
- R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 15 carbon atoms;
- R.sup.2 represents a 6-methyl-5-heptenyl group of a 2,6-dimethyl-5-heptenyl group;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.