De(mycinosyloxy)tylosin and process for its production
AssigneeEli Lilly and Company
InventorsRichard H. Baltz, Gene M. Wild, Eugene T. Seno
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Abstract
23-De(mycinosyloxy)tylosin (DMOT) which has the formula: ##STR1## 20-dihydro-DMOT, specified acyl ester derivatives, and the acid addition salts thereof are useful antibacterial agents. New methods of making 23-deoxy-5-O-my-caminosyltylonolide (DOMT) and 20-dihydro-DOMT by mild acid hydrolysis of DMOT and 20-dihydro-DMOT, respectively, are included.
Claims15
A compound selected from the group consisting of (1) 23-de(mycinosyloxy)tylosin which has the structure:
- ##STR5## and (2) the acid addition salts of 23-de(mycinosyloxy)-tylosin.
A compound selected from the group consisting of (1) 20-dihydro-23-de(mycinosyloxy)tylosin which has the structure:
- ##STR6## and (2) the acid addition salts of 20-dihydro-23-de(mycinosyloxy)tylosin.
A compound selected from the group consisting of the 2'-monoesters of 23-de(mycinosyloxy)-tylosin and of 20-dihydro-23-de(mycinosyloxy)tylosin, and their acid addition salts, wherein each of said esters is an ester of a monocarboxylic acid or a hemiester of a dicarboxylic acid, each of 2 to 18 carbon atoms.
Dependencies are inferred from the claim text.