Demycinosyltylosin and process for its production
AssigneeEli Lilly and Company
InventorsRichard H. Baltz, Gene M. Wild, Eugene T. Seno
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Abstract
23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.
Claims15
A compound selected from the group consisting of (1) 23-demycinosyltylosin which has the structure:
- ##STR4## and (2) the acid addition salts of 23-demycinosyltylosin.
A compound selected from the group consisting of (1) 20-dihydro-23-demycinosyltylosin which has the structure:
- ##STR5## and (2) the acid addition salts of 20-dihydro-23-demycinosyltylosin.
A compound selected from the group consisting of the 2'-monoesters of 23-demycinosyltylosin and of 20-dihydro-23-demycinosyltylosin, and their acid addition salts, wherein each of said esters is an ester of a monocarboxylic acid or a hemi-ester of a dicarboxylic acid, each of 2 to 18 carbon atoms.
Dependencies are inferred from the claim text.