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US 4,321,257 AGranted
Potentiated medicaments
AssigneeJohnson & Johnson
InventorTibor Sipos
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AssigneeJohnson & Johnson
InventorTibor Sipos
Estimating the term…
Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylanilides, organo-metallic antiseptics, antibiotics, halogens, organic halogen derivatives and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is a cyclohexyl phenol which may have a substituent on the phenyl ring selected from the group consisting of C.sub.1 to C.sub.3 alkyl and alkoxy, hydroxy, halo, amino and alkyl and dialkyl amino-substituents. These novel compositions find special applications as surgical scrub solutions, and for use in dressing topical wounds where the presence of blood and wound exudate would otherwise inhibit the action of the antimicrobial agent if it were to be used alone.
An antimicrobial composition comprising effective amounts of an antimicrobial agent and a potentiator therefor, wherein said potentiator is at least one cyclohexyl phenol having the structure ##STR10## where R.sub.8 is hydrogen, C.sub.1 to C.sub.3 alkyl, C.sub.1 to C.sub.3 alkoxy, hydroxy, halogen, amino, or mono or di C.sub.1 to C.sub.3 alkyl amino, provided that the total number of carbon atoms in the alkyl groups substituted on the amino does not exceed 5, and said antimicrobial agent is a member selected from the group consisting of the antibiotics, bisdiguanides, quaternary ammonium compounds, carbanilides, salicylanilides, hydroxydiphenyls, organo-metallic antiseptics, halogen antiseptics, and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone.
In the antimicrobial treatment of a microbe contaminated surface containing bodily secretions and fluids comprising applying to said surface an effective amount of an antimicrobial agent selected from the group consisting of the antibiotics, bisdiguanides, quaternary ammonium compounds, carbanilides, salicyanilides, hydroxydiphenyls, organo-metallic antiseptics, halogen antiseptics, and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone, the improvement comprising potentiating the activity of the antimicrobial agent by applying the same in conjunction with an effective amount of a potentiator having the structure:
An antimicrobial composition comprising effective amounts of an antimicrobial agent and a potentiator therefor, wherein said potentiator is at least one cyclohexyl phenol having the structure ##STR12## where R.sub.8 is hydrogen, C.sub.1 to C.sub.3 alkyl, C.sub.1 to C.sub.3 alkoxy, hydroxy, halogen, amino, or mono or di C.sub.1 to C.sub.3 alkyl amino, provided that the total number of carbon atoms in the alkyl groups substituted on the amino does not exceed 5, and said antimicrobial agent is an antifungal agent selected from the group consisting of griseofulvin, mycostatin and miconazole.
In the antimicrobial treatment of a microbe contaminated surface containing bodily secretions and fluids, comprising applying to said surface an effective amount of an antifungal agent selected from the group consisting of griseofulvin, mycostatin and miconazole, the improvement comprising potentiating the activity of the anti-fungal agent by applying the same in conjunction with an effective amount of a potentiator having the structure:
Dependencies are inferred from the claim text.