Alicyclic amides having a physiological cooling effect
AssigneeWilkinson Sword Limited
InventorsDavid G. Rowsell, David J. Spring, Roger Hems
Life of this patent
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Abstract
Alkyl-substituted alicyclic carboxylic acids, esters and amides are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.
Claims15
In a consumer product for application to or consumption by the human body comprising a consumer product base and, as adjuvants in said base, (i) at least one of the following:
- a flavourant, colourant, perfuming agent, surface active agent or antiseptic agent, and (ii) an ingredient capable of stimulating the cold receptors of the nervous system of the surface tissues of the body in those parts of the human body with which the product comes in contact during use, the improvement which comprises using as the cold receptor stimulating ingredient an effective amount of a cold receptor stimulating alicyclic amide of the formula:
- ##STR11## where n is 0 or an integer of from 2-6 inclusive;
- x has a value of 1, 2 or 3;
- R is C.sub.1 -C.sub.5 alkyl, at least one R group being in a 1, 2 or 3 position relative to the CONR'R" group and the total number of carbon atoms provided by the R groups and the carbocycle to which they are attached being from 8-14;
- and
- R' and R" together represent a straight or branched chain alkylene group of up to 8 carbon atoms, the opposite ends of which group are joined to the nitrogen atom to form a 5- or 6-membered heterocycle, or a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --group.
A method of stimulating the cold receptors of the nervous system of the human body which comprises applying thereto a composition as defined in claim 26.
In a tobacco or tobacco-containing manufacture comprising tobacco and an agent capable of stimulating the cold receptors of the nervous system of the nasal or oral mucosa when brought into contact therewith upon use of the manufacture, the improvement which comprises using as said agent an effective amount of a cold receptor stimulating amide of the formula:
- ##STR13## where n is o or an integer of from 2-6 inclusive;
- x has a value of 1, 2 or 3;
- R is C.sub.1 -C.sub.5 alkyl, at least one R group being in a 1, 2 or 3 position to the CONR'R" group and the total number of carbon atoms provided by the R groups and the carbocycle to which they are attached being from 8-14;
- and
- R' and R" together represent a straight or branched chain alkylene group of up to 8 carbon atoms, the opposite ends of which group are joined to the nitrogen atom to form a 5- or 6-membered heterocycle, or a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- group.
A method of stimulating the cold receptors of the nervous system of the nasal and oral mucosa which comprises contacting said mucosa with an effective amount of a cold receptor stimulating amide entrained in a stream of tobacco smoke said amide being of the formula ##STR14## where n is o or an integer of from 2-6 inclusive;
- x has a value of 1, 2 or 3;
- R is C.sub.1 -C.sub.5 alkyl, at least one R group being in a 1, 2 or 3 position relative to the CONR'R" group and the total number of carbon atoms provided by the R groups and the carbocycle to which they are attached being from 8-14;
- and
- R' and R" together represent a straight or branched chain alkylene group of up to 8 carbon atoms, the opposite ends of which group are joined to the nitrogen atom to from a 5- or 6-membered heterocycle, or a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- group.
Dependencies are inferred from the claim text.