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US 4,318,853 AGranted
9.beta.,11.beta.-Epoxy-5.beta.-corticoids
AssigneeThe Upjohn Company
InventorsDonald E. Ayer, Carl A. Schlagel
Life of this patent
Estimating the term…
Abstract
17.alpha.-Acyloxy-5.alpha.-pregnanes (I) and 17.alpha.-acyloxy-5.alpha.-pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.
Claims20
A 5.beta.-9,11-epoxy steroid of the formula:
- where R.sub.2, R.sub.6, R.sub.7, R.sub.16.alpha., R.sub.16.beta., R.sub.17,
A process for preparing a 5.beta.-9,11-epoxy steroid of the formula:
- ##STR2## which comprises (1) hydrogenating a compound of the formula:
- ##STR3## in the presence of a hydrogenating catalyst and (2) separating the 5.beta.-isomer from the 5.alpha.-isomer where R.sub.2, R.sub.6, R.sub.7, R.sub.16.alpha., R.sub.16.beta., R.sub.17, R.sub.21, .about., and are defined in the specification.
Dependencies are inferred from the claim text.