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US 4,316,896 AGranted
Aminoacid derivatives as antihypertensives
AssigneeMerck & Co., Inc.
InventorsEugene D. Thorsett, Arthur A. Patchett, Elbert E. Harris, Alan L. Maycock
Life of this patent
Estimating the term…
Abstract
The invention relates to new phosphoryl aminoacid derivatives and related compounds which are useful as antihypertensives.
Claims9
A compound of the formula:
- ##STR14## wherein n is 0 or 1
- R is lower alkyl, phenyl lower alkyl, hydroxyphenyl lower alkyl, hydroxy lower alkyl, aminoloweralkyl, guanidino lower alkyl, imidazoyl lower alkyl, indolyl lower alkyl, mercapto lower alkyl, lower alkyl mercapto lower alkyl;
- R.sub.3 and R.sub.4 may be connected together to form an alkylene bridge of from 2 to 4 carbon atoms or an alkylene bridge of from 2 to 3 carbon atoms and one sulfur atom;
- X is NR.sup.5, S where R.sup.5 =H or lower alkyl;
- R.sub.1 is hydrogen, lower alkyl, phenyl lower alkyl or phenyl or substituted phenyl wherein the substituent is halo, lower alkoxy or lower alkyl;
- R.sub.2 is hydrogen, lower alkyl, phenyl lower alkyl, or phenyl or substituted phenyl wherein the substituent is halo, lower alkoxy or lower alkyl and pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.