Composition for topical application and method for preparing the same
AssigneeToko Yakuhin Kogyo Kabushiki Kaisha
InventorsTakuzo Kamishita, Kazuhiko Kamishita
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Abstract
An anti-inflammatory, analgesic and anti-pruritic compositions for topical application is made by mixing an aqueous alcoholic solution of methanol or camphor with sufficient water soluble carboxyvinyl polymer to give a viscosity of 2,000 to 20,000 centipoises at 20.degree. C., sufficient basic agent, such as an amine, to neutralize the carboxyl groups to a pH of 6.0-7.5 and a small amount of sodium chloride.
Claims2
A composition for topical application comprising a mixture of:
- (a) an aqueous solution of 20 to 60% by weight of an alcohol selected from the group consisting of ethanol, ethanol denatured with methanol, ethanol denatured with geraniol, said aqueous solution containing a therapeutically effective amount of an ingredient selected from menthol, camphor and a mixture of menthol and camphor;
- (b) a carboxyvinyl polymer in an amount of 0.1 to 1.5% by weight based on the weight of said composition;
- (c) a water-soluble basic substance selected from the group consisting of an alkylamine, a dialkylamine, a trialkylamine, an alkanolamine, a dialkanolamine, a trialkanolamine, trimethylolaminomethane, and ammonia in an amount effective for neutralizing the carboxyvinyl polymer;
- and (d) 0.002 to 1% by weight of sodium chloride based on the weight of said composition, said composition having a pH of 6.0 to 7.5 and a viscosity of 2,000 to 20,000 centipoises at 20.degree. C.
A method for preparing a composition for topical application having a pH 6.0 to 7.5 and a viscosity of 2,000 to 20,000 centipoises at 20.degree. C., which comprises admixing an aqueous carboxyvinyl polymer solution containing said carboxyvinyl polymer in an amount to provide 0.1 to 1.5% by weight of said carboxyvinyl polymer based on the weight of said composition with an aqueous alcoholic solution containing 20 to 60% by weight of an alcohol selected from the group consisting of ethanol, ethanol denatured with methanol, ethanol denatured with geraniol, said aqueous alcoholic solution containing a therapeutically effective amount of an ingredient selected from menthol, camphor and a mixture of menthol and camphor and adding to the resulting admixture, with stirring, a water-soluble basic substance selected from the group consisting of an alkylamine, a dialkylamine, a trialkylamine, an alkanolamine, a dialkanolamine, a trialkanolamine, trimethylolaminomethane and ammonia in an amount effective for neutralizing said carboxyvinyl polymer and adjusting the pH of the resulting system to 6.0 to 7.5, and adding sodium chloride to said resulting system in an amount to bring the sodium chloride content of said composition to 0.002 to 1% by weight.
Dependencies are inferred from the claim text.