Back to results
US 4,312,870 AGranted
Pyrazoloquinolines
AssigneeCiba-Geigy Corporation
InventorNaokata Yokoyama
Life of this patent
Estimating the term…
Abstract
2-Aryl-pyrazolo[4-3-c]quinolin-3-ones, e.g. those of the formula ##STR1## and pharmaceutically acceptable acyl derivatives or salts thereof, are psychoactive agents useful in the treatment of anxiety or depression.
Claims16
A 2-aryl-pyrazolo[4,3-c]quinolin-3-one compound of the formulae ##STR10## wherein Ph is 1,2-phenylene, unsubstituted or substituted by up to 3 identical or different members selected from lower alkyl, lower alkoxy, lower alkylthio, hydroxy, halogeno, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, cyano, carbamoyl and carboxy;
- R is unsubstituted or substituted phenyl as defined by H--Ph, pyridyl, lower alkylpyridyl or halogenopyridyl;
- R.sub.1 is hydrogen, lower alkyl or lower (hydroxy, dialkylamino or H--Ph)-alkyl;
- and R.sub.2 is hydrogen or lower alkyl;
- their 3-hydroxy-tautomers;
- lower alkanoyl, carbamoyl, mono- or di-lower alkylcarbamoyl derivatives of said (hydroxy or amino)-(phenyl or phenylene) compounds;
- or pharmaceutically acceptable alkali metal or acid addition salts thereof.
3 more elements
Dependencies are inferred from the claim text.