Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions
AssigneeAmerican Cyanamid Company
InventorsJay E. Birnbaum, Luc Van Humbeeck, Franz Dessy
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Abstract
This application discloses a process for producing cutaneous vasodilation which comprises the topical administration to an individual with a vasospastic or ischemic condition of an effective dosage of a prostaglandin vasodilator of the natural or synthetic prostaglandin analogs of the PGE, PGA, or PGF.sub..beta. types.
Claims9
A method for producing an increase in local cutaneous and deep vessel circulation for individuals suffering from peripheral vascular disease of the arteriospastic and occlusive types which comprises topically administering to an individual suffering from said peripheral vascular disease an effective amount of a compound of the formula:
- ##STR11## or a racemic mixture of that formula and the mirror image thereof wherein X is ##STR12## and R.sub.14 is selected from the group consisting of hydroxyl, C.sub.1 -C.sub.6 alkoxy, --CH.sub.2 OH and --CH.sub.2 OR.sub.15 wherein R.sub.15 is C.sub.2 -C.sub.6 alkanoyl, and when R.sub.14 is hydroxy, the pharmacologically acceptable cationic salts thereof.
Dependencies are inferred from the claim text.