Synthesis of vitamin E and quinone intermediates
AssigneeHoffmann-La Roche Inc.
InventorsGary L. Olson, Gabriel Saucy
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Abstract
A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.
Claims4
A process for producing a compound of the formula ##STR25## wherein R is ##STR26## comprising oxidizing a compound of the formula ##STR27## wherein R is as above in the presence of a salt of the formula:
- ##STR28## in an inert organic solvent medium wherein R.sub.11, R.sub.12 and R.sub.13 are alkyl containing from 1 to 20 carbon atoms and R.sub.14 is alkyl containing from 8 to 20 carbon atoms.
The process for producing a compound of the formula ##STR29## wherein R is ##STR30## comprising oxidizing a compound of the formula ##STR31## wherein R is as above with a compound of the formula:
- ##STR32## wherein M is an alkali metal;
- in the presence of 0.01-5.0 equivalents of a quaternary ammonium salt of the formula:
- ##STR33## wherein R.sub.11, R.sub.12 and R.sub.13 are alkyl containing from 1 to 20 carbon atoms and R.sub.14 is alkyl containing from 8 to 20 carbon atoms and Y is halogen
- in a two phase aqueous-organic solvent medium.
Dependencies are inferred from the claim text.