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US 4,310,461 AGranted
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
AssigneeE. R. Squibb & Sons, Inc.
InventorsJohn Krapcho, Peter C. Wade
Life of this patent
Estimating the term…
Abstract
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.
Claims13
A compound having the formula ##STR7## wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, alkyl, cycloalkyl, 1-adamantyl, aryl, arylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkylsulfonyl, arylsulfonyl, or arylvinylcarbonyl;
- R.sub.3 is hydrogen, alkyl, aryl, arylalkyl, alkanoyl or arylcarbonyl;
- R.sub.4 is hydrogen, alkyl, alkylthio, or trifluoromethyl;
- R.sub.5 is hydrogen, alkyl, or arylalkyl;
- n is 0, 1 or 2;
- and
- p is 1 or 2;
- or a salt thereof, or symmetrical dimer thereof;
- wherein the term "aryl" refers to phenyl, 1-naphthyl, 2-naphthyl or phenyl substituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, phenyl or trifluoromethyl groups;
- the term "cycloalkyl" refers to groups having 3 to 7 carbon atoms;
- the term "alkanoyl" refers to groups having up to 9 carbon atoms;
- and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
8 more elements
Dependencies are inferred from the claim text.