Topical application of medication by ultrasound with coupling agent
AssigneeThe Curators of the University of Missouri
InventorMostafa S. Fahim
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Abstract
A method of topically applying an effective medication in an emulsion coupling agent by ultrasound. More particularly, a method of treating a skin condition by applying a medication in an emulsion coupling agent and massaging it into the affected area with ultrasonic vibrations thereby causing the medication to penetrate into the skin. Specifically, a method and composition for the treatment of Herpes Simplex Type 1 and Type 2 lesions. Also specifically, a method and composition for the treatment of demidox mites.
Claims6
In the treatment of Herpes Simplex lesions, a method for the selective localized intracellular administration of a medication including urea and a zinc compound in a coupling agent, the urea and zinc compound being present in an effective amount, which comprises applying said medication to the affected area and massaging said medication therein with an ultrasonic applicator coupled to an ultrasonic generator, said applicator continuously vibrating at a frequency of at least 1,000 KHZ and having an effective power level from about 1 watt per sq. cm to about 3 watts per sq. cm for a time sufficient to obtain intracellular penetration of said medication without causing undo cell wall deterioration whereby the zinc amplifies the mechanical effects of the ultrasonic vibrations and the urea acts as an antiviral agent.
Dependencies are inferred from the claim text.