Process for the O-methylation of hydroxyaporphines
AssigneeWarner-Lambert Company
InventorsJohannes Hartenstein, Gerhard Satzinger
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Abstract
A process for the O-methylation of hydroxyaporphines is disclosed. This process utilizes a trimethylphenylammonium base as the alkylating agent.
Claims8
Process for the O-methylation of hydroxyaporphines, wherein the phenolic hydroxyl groups of a compound of the general formula ##STR5## in which at least one of the symbols R.sub.1 to R.sub.7 signifies a hydroxyl group, whereas the other symbols represent hydrogen atoms or substituents which are inert under the reaction conditions and R.sub.8 is a lower alkyl radical, are O-methylated in an inert solvent with a compound of the general formula ##STR6## in which X.sup.- is a hydroxyl group or a lower alkoxy radical, whereafter the reaction product is isolated and, if desired, converted into a pharmacologically acceptable salt.
Dependencies are inferred from the claim text.