Preparation of 11-deoxy anthracycline antibiotics
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsGiuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
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Abstract
Anthracycling antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Macromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under numbr No. 31366 ATCC.
Claims6
A process for producing an antibiotic complex including a mixture of the compounds having the formula:
- ##STR4## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 and a salt thereof, said process comprising cultivating the microorganism Micromonospora peucetica sp. nova under aerobic conditions in an aqueous culture medium containing an assimilable source of carbon, an assimilable source of nitrogen and mineral salts and recovering said antibiotic complex from the culture medium.
A biologically pure culture of the microorganism Micromonospora peucetica sp. nova, having the identifying characteristics of ATCC 31366, said culture being capable of producing anthracycline antibiotics in recoverable quantities.
Dependencies are inferred from the claim text.