Pyridinecarbonamido-oxy or thio loweralkyl-1-(diloweralkylaminoloweralkyl)benzene and derivatives thereof, compositions containing same and method of using same

Abstract

An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur; Y is oxo, thioxo, or cyanoimino; a is an integer of 1 to 3; b is an integer of 0 to 3; c is an integer of 1 to 4; R.sup.1 is alkyl; R.sup.2 is hydrogen or alkyl; or R.sup.1 and R.sup.2 taken together represent pyrrolidinyl; R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R.sup.3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy; R.sup.4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; or R.sup.3 and R.sup.4 taken together represent alkylidene or aralkylidene; with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H.sub.2 blockers, especially peptic ulcer remedies, are provided via several routes.

Dependencies are inferred from the claim text.