Maytansinoids
AssigneeTakeda Chemical Industries, Ltd.
InventorsOsamu Miyashita, Hiroshi Akimoto
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Abstract
Novel maytansinoids of the formula: ##STR1## wherein X is hydrogen or chlorine, R.sup.1 is C.sub.2-4 alkyl, R.sup.2 is C.sub.2-8 alkyl which may be substituted or methyl which is substituted, have antimicrobial, antimitotic and antitumor activities.
Claims12
A compound of the formula:
- ##STR6## wherein X is hydrogen or chlorine,
- R.sup.1 is C.sub.2-4 alkyl
- R.sup.2 is C.sub.1-5 alkyl substituted with oxo, C.sub.2-5 alkoxycarbonyl, or/and phenyl.
C.sub.20 -.beta.,.beta.-diethoxyethyl ether of 20-demethoxy-20-hydroxymaytansinol 3-isobutylate.
A pharmaceutical composition suitable for inhibiting the growth of tumor cells and prolonging the survival time of a tumor-bearing warm-blooded animal, which contains an amount effective for inhibiting the growth of tumor cells and prolonging the survival time of a tumor-bearing warm-blooded animal of a compound of the formula:
- ##STR7## wherein X is hydrogen or chlorine,
- R.sup.1 is C.sub.2-4 alkyl
- R.sup.2 is C.sub.1-5 alkyl substituted with oxo, C.sub.2-5 alkoxycarbonyl, or/and phenyl.
A method for inhibiting the growth of tumor cells and prolonging the survival time of a tumor-bearing warm-blooded animal, which comprises administering to said animal an amount effective for inhibiting the growth of tumor cells and prolonging the survival time of a tumor-bearing animal of a compound of the formula:
- ##STR8## wherein X is hydrogen or chlorine,
- R.sup.1 is C.sub.2-4 alkyl
- R.sup.2 is C.sub.1-5 alkyl substituted with oxo, C.sub.2-5 alkoxycarbonyl, or/and phenyl.
Dependencies are inferred from the claim text.