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US 4,309,424 AGranted
4-Phenyl-1,3-benzodiazepines
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsLawrence L. Martin, Manfred Worm, Charles A. Crichlow
Life of this patent
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Abstract
Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
Claims81
A compound of the formula ##STR31## in which R is hydrogen or alkyl of from 1 to 5 carbon atoms;
- R.sub.1 is hydrogen, alkyl of from 1 to 5 carbon atoms, cycloalkylalkyl of from 4 to 8 carbon atoms or aralkyl having from 1 to 5 carbons in the alkyl moiety, X and Y are the same or different and each can be hydrogen, chlorine, bromine, fluorine, methoxy, alkyl of from 1 to 3 carbon atoms, hydroxy, or trifluoromethyl;
- m is the integer 1 or 2;
- n is the integer 1, 2 or 3;
- and the optical antipodes thereof;
- and a physiologically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.