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AssigneeCiba-Geigy Corporation
InventorMichel Biollaz
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19-Oxygenated steroid compounds of the pregnane series of the formula I ##STR1## in which R.sup.1 represents a hydrogen atom, and R.sup.2 represents an .alpha.-oriented lower alkanoylthio group, or R.sup.1 and R.sup.2 together represent a carbon-carbon bond or an .alpha.-or .beta.-oriented methylene radical, R.sup.3 represents a free hydroxymethyl group or a hydroxymethyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a formyl group, a carboxyl group or a lower alkoxycarbonyl group, and R.sup.4 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, and corresponding 1,2-dehydro derivatives have valuable aldosterone-antagonizing properties with a minimum effect on sexual functions. As the compounds reduce the excessive sodium retention and potassium excretion induced by aldosterone, they are especially useful as the active ingredient in pharmaceutical preparations for alleviating diseases involving hyperaldosteronismus in man and other warm-blooded animals.
A 19-oxygenated steroid of the pregnane series having the formula I ##STR10## in which R.sup.1 represents a hydrogen atom;
7.alpha.-Acetylthio-19,21-dihydroxypregn-4-ene-3,20-dione 19-acetate.
7.alpha.-Acetylthio-21-hydroxy-19-methoxypregn-4-ene-3,20-dione 21-acetate.
An aldosterone-antagonizing pharmaceutical composition comprising a correspondingly effective amount of a compound of formula I ##STR11## in which R.sup.1 represents a hydrogen atom;
A therapeutic method for alleviating pathological conditions which are consequent to hyperaldosteronism in a warm-blooded animal which consists in the administration to said animal in need thereof of an effective amount of an aldosterone-antagonizing pharmaceutical composition comprising a correspondingly effective amount of a compound of formula I ##STR12## in which R.sup.1 represents a hydrogen atom;
Dependencies are inferred from the claim text.