Stabilized parenterally administrable solutions
AssigneeA. Nattermann & Cie GmbH
InventorsMiklos Ghyczy, Gotz Ritzmann, Adorjan Erdos, Eugen Etschenberg
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Abstract
Solutions of anti-inflammatory acrylacetic and arylpropionic acid derivatives are stabilized by addition of phospholipids. The solutions are suitable for parenteral administration; they are well tolerated and have a long-lasting action.
Claims21
A method of treating a subject suffering from an inflammatory illness which comprises administering parenterally to said subject an effective amount of a solution comprising a water-soluble complex of a phospholipid with a non-steroid antiphlogistic comprising an inflammation-inhibiting derivative of an arylacetic or arylpropionic acid selected from the group consisting of 2-(4-isobutylphenyl)-propionic acid, 2-(6-methoxy-2-naphthyl)-propionic acid, 2-(2-fluorobiphenyl-4-yl)-propionic acid, 4-allyloxy-3-chlorophenylacetic acid, 2-(3-benzylphenyl)-benzoic acid, 2-(2,6-dichlorophenylamino)-phenylacetic acid and 2-(3-phenyloxyphenyl)-acetic acid, the molar ratio of said derivative to said phospholipid ranging from about 1:0.3 to 1:10.
A parenterally administrable solution comprising a water-soluble complex of a phospholipid with a non-steroid antiphlogistic comprising an inflammation-inhibiting derivative of an arylacetic or arylpropionic acid selected from the group consisting of 2-(4-isobutylphenyl)-propionic acid, 2-(6-methoxy-2-naphthyl)-propionic acid, 2-(2-fluorobiphenyl-4-yl)-propionic acid, 4-allyloxy-3-chlorophenylacetic acid, 2-(3-benzylphenyl)-benzoic acid, 2-(2,6-dichlorophenylamino)-phenylacetic acid and 2-(3-phenyloxyphenyl)-acetic acid, the molar ratio of said derivative to said phospholipid ranging from about 1:0.3 to 1:10.
Dependencies are inferred from the claim text.