Stable injectable solutions of indoleacetic acid derivatives
AssigneeA. Nattermann & Cie GmbH
InventorsMiklos Ghyczy, Gotz Ritzmann, Adorjan Erdos, Eugen Etschenberg
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Abstract
Stable solutions of anti-inflammatory indoleacetic acid derivatives and indanacetic acid derivatives comprise the said derivative and a phospholipid. Such solutions can be administered by injection and have a long-lasting therapeutic effect.
Claims14
A method of treating an inflammatory illness which comprises administering to a subject suffering therefrom an effective amount of a solution comprising a water-soluble complex of a phospholipid and an inflammation-inhibiting indoleacetic acid derivative selected from the group consisting of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid glycolic acid ester, and 1-cinnamoyl-5-methoxy-2-methyl-indole-3-acetic acid, the molar ratio of said derivative to said phospholipid ranging from about 1:0.5 to 1:10.
An injectable stable solution having an inflammation-inhibiting action, comprising a water-soluble complex of a phospholipid and an inflammation-inhibiting indoleacetic acid derivative selected from the group consisting of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-acetic acid glycolic acid ester and 1-cinnamoyl-5-methoxy-2-methyl-1-indole-3-acetic acid, the molar ratio of said derivative to said phospholipid ranging from about 1:0.5 to 1:10.
Dependencies are inferred from the claim text.