Method for the inhibition of immune response
AssigneeBurroughs Wellcome Co.
InventorsGerald Wolberg, Thomas P. Zimmerman
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Abstract
Adenosine derivatives for inhibition of immune response are disclosed. Adenosine derivatives of formula (I) ##STR1## wherein R.sup.1 is amino or lower alkyl amino; R.sup.2 is hydrogen or an aliphatic carboxylic acid residue; and R.sup.3 is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue, are useful as inhibitors of immune response. The activity is potentiated by derivatives of homocysteine and homocystine. Particularly useful is 3-deaza-adenosine both alone and in combination with L-homocysteine thiolactone, Pharmaceutical formulations of compounds of formula (I) alone and with potentiators are provided.
Claims14
A method for the inhibition of immune response in a mammal comprising the administration, to a mammal in need thereof, of an immune response inhibiting, non-toxic amount of 3-deazaadenosine or a pharmaceutically acceptable salt thereof.
A method for the inhibition of immune response in a mammal in need thereof which comprises the administration to said mammal of an immune response inhibition amount or less of 3-deazaadenosine or a pharmaceutically acceptable salt thereof together with a potentiator selected from the group consisting of L-homocysteine, D-homocysteine, L-homocysteine thiolactone, D-homocysteine thiolactone, L-homocystine, D-homocystine and their selenium analogues.
A pharmaceutical preparation for use in medicine which comprises a compound of 3-deazaadenosine or a pharmaceutically acceptable salt thereof together with a potentiating amount of L-homocysteine, D-homocysteine, L-homocysteine thiolactone, D-homocysteine thiolactone, L-homocystine, D-homoscystine and their selenium analogues, the amount of compound or salt to potentiator present is in the ratio of 1:100 to 1:10.
Dependencies are inferred from the claim text.