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US 4,309,404 AGranted
Sustained release pharmaceutical compositions
AssigneeAmerican Home Products Corporation
InventorsRichard J. DeNeale, Paul C. Guley, George Milosovich
Life of this patent
Estimating the term…
Abstract
Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.
Claims15
A sustained release pharmaceutical composition comprising a compressed core, a seal coating surrounding the core and a sugar coating surrounding the seal coated core wherein,
- (a) the core comprises by weight of the core about 31% to about 53% of the drug, about 7% to about 14.5% carboxypolymethylene, about 0% to about 3% zinc oxide, about 4.5% to about 10% stearic acid and about 3% to about 30% mannitol;
- (b) the seal coating comprises a film coating selected from the group consisting of enteric and non-enteric materials and mixtures thereof;
- and
- (c) the sugar coating comprises sugar and a loading dose of said drug. and with the proviso that when the seal coating consists essentially of an enteric coating material the drug is other than propranolol or its pharmaceutically acceptable salts.
1 more element
A sustained release pharmaceutical composition comprising a compressed core containing a drug, a seal coating surrounding the core and a sugar coating surrounding the seal coated core wherein,
- (a) the core comprises by weight of the core about 31% to about 53% of at least one drug, about 7% to about 14.5% carboxypolymethylene, about 0% to about 3% zinc oxide, about 4.5% to about 10% stearic acid and about 3% to about 30% mannitol;
- (b) the seal coating comprises a film coating selected from the group consisting enteric and of non-enteric materials and mixtures thereof;
- and
- (c) the sugar coating comprises sugar and a loading dose of at least one drug contained in the core;
- and with the proviso that when the seal coating consists essentially of an enteric coating material the drug is other than propranolol or its pharmaceutically acceptable salts.
2 more elements
Dependencies are inferred from the claim text.