Benzopyrane derivatives
AssigneeCiba-Geigy Corporation
InventorPier G. Ferrini
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Abstract
New benzopyrane derivatives of the general formula ##STR1## in which R is free, esterified or amidated carboxyl, Ph is 1,2-phenylene which contains the group R--CO--NR.sub.3 -- and is otherwise unsubstituted or is substituted, X is a group of the formula --CO--CR.sub.1 .dbd.CR.sub.2 --, in which R.sub.1 and R.sub.2 independently of one another are hydrogen, acyl or a substituted or unsubstituted hydrocarbon radical or a hetero-analogue thereof, or conjointly are 3-membered to 5-membered lower alkylene, and R.sub.2 can also be free or etherified hydroxyl or hydroxyl etherified by an organic carboxylic acid, and R.sub.3 is hydrogen or lower alkyl, are useful as anti-allergic agents.
Claims4
A benzopyrane compound having the formula ##STR14## in which R.sub.o is glycoloyl or lower alkoxy-acetyl having up to 6 carbon atoms, Ph' is 1,2-phenylene which contains the group R.sub.o --NH-- and, in addition, is otherwise unsubstituted or is additionally substituted by lower alkyl, lower alkoxy, halogen, hydroxyl and trifluoromethyl, R.sub.1 ' and R.sub.2 ' conjointly are tri-, tetra- or penta-methylene, or R.sub.1 ' is hydrogen, lower alkanoyl, carboxyl, lower alkoxy-carbonyl, lower alkyl, or phenyl or pyridyl which are unsubstituted or substituted by lower alkyl, lower alkoxy, halogen, hydroxyl and trifluoromethyl, and R.sub.2 ' has one of the meanings given for R.sub.1 ' or is hydroxyl, lower alkoxy, or lower alkanoyloxy, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.