Indeno and naphth[1,2-d]azepines
AssigneeCiba-Geigy Corporation
InventorNorbert Gruenfeld
Life of this patent
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Abstract
Hydrogenated 1-aminoalkyl indeno- or -naphth[1,2-d]azepines, e.g. those of the formula ##STR1## Am'=NH.sub.2, (alkyl, alkenyl, alkynyl, hydroxyalkyl, cycloalkyl, or benzyl)amino, its N-lower alkyl derivatives; alkyleneimino morpholino or piperazino R.sub.o-3 =H, OH, alkyl, alkoxy, halo or CF.sub.3 R.sub.4,5 =H or alkyl; X=H.sub.2 or 0 m=1 or 2; q=0 or 1 and salts thereof are potassium-sparing diuretic agents.
Claims5
A compound of the formula ##STR10## wherein Ph is unsubstituted 1,2-phenylene, or 1,2-phenylene substituted by up to 3 members selected from lower alkyl, hydroxy, mercapto, lower alkoxy, lower alkylthio, lower alkenyloxy, halogeno and trifluoromethyl;
- C.sub.m H.sub.2m is lower alkylene separating the adjacent atoms by one or two carbon atoms;
- C.sub.n H.sub.2n is lower alkylene separating the adjacent atoms by two carbon atoms;
- p is an integer from 1 to 7;
- Am is amino, mono- or di-lower alkylamino;
- X represents two hydrogens and R is hydrogen, lower alkyl or hydroxyalkyl;
- or a therapeutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.